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Impact of nutrition and polyphenols on the pathophysiology of endometriosis: a systematic review
| Resumo: | Endometriosis, a very prevalent and disturbing gynecological disease that affects reproductive age women, is difficultly controlled in the long-term by currently available treatments. This prompts patients to look for self-controlled interventions, such as dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin and resveratrol, three polyphenols found in dietary sources, can act as natural interventions to control endometriosis. The review was guided by PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search was carried out in PubMed and Scopus to gather together all the articles available from the past years that study the specific actions of curcumin, resveratrol, or quercetin in endometriosis pathophysiology. Twenty-three articles were included - 8 publications about curcumin, 1 about quercetin and 14 about resveratrol. All type of study designs including experimental data were considered. For the assessment of the quality of the selected studies, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used; the studies included globally have "good quality". By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis and angiogenesis, curcumin, quercetin and resveratrol, showed to have important beneficial effects in endometriosis progression. Only a clinical trial was included in our selection, but we found evidence to support that these compounds could potentially be used as dietary agents for the control of endometriosis. However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis. |
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| Assunto: | Medical and Health sciences Ciências médicas e da saúde |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | Restrito |
| Instituição associada: | Repositório Aberto da Universidade do Porto |
| Idioma: | inglês |
| Origem: | Repositório Aberto da Universidade do Porto |
| Resumo: | Endometriosis, a very prevalent and disturbing gynecological disease that affects reproductive age women, is difficultly controlled in the long-term by currently available treatments. This prompts patients to look for self-controlled interventions, such as dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin and resveratrol, three polyphenols found in dietary sources, can act as natural interventions to control endometriosis. The review was guided by PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search was carried out in PubMed and Scopus to gather together all the articles available from the past years that study the specific actions of curcumin, resveratrol, or quercetin in endometriosis pathophysiology. Twenty-three articles were included - 8 publications about curcumin, 1 about quercetin and 14 about resveratrol. All type of study designs including experimental data were considered. For the assessment of the quality of the selected studies, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used; the studies included globally have "good quality". By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis and angiogenesis, curcumin, quercetin and resveratrol, showed to have important beneficial effects in endometriosis progression. Only a clinical trial was included in our selection, but we found evidence to support that these compounds could potentially be used as dietary agents for the control of endometriosis. However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis. |
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