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NOVEL ANTI-INFLAMMATORY AND IMMUNOMODULATION EFFECTS OF ROSE ON THE ENDOTHELIUM IN NORMAL AND HYPOXIC INVITRO CONDITIONS
| Summary: | Aims Inflammation is common in clinical practice and often results in significant complications. The study was performed in search of a novel anti-inflammatory agent for inflammation modulation which would be useful for cardiovascular disorders and various clinical scenarios. Materials and methods A crushed red rose extract was prepared from the petals, and it was processed for analysis. The extract was tested on HUVEC cells at various concentrations. By microscopic analysis of cells, a safe concentration was identified, and the levels below the safe limit were tested at 72 hours and seven days for selected cytokines secretion. Results Majority of the tested Inflammatory cytokine secretion was reduced by the treatment of red rose extract on the cells. VEGF and angiogenic cytokine levels were reduced, but VEGF-R2 levels were maintained after the cell treatment. Below the safe concentration limit (0.5%) there were only minimal changes in the cytokines levels tested at various dilutions. Conclusion There is potential for a red rose extract treatment in the regulation of inflammatory cytokines secretion. Further studies need to be performed to identify the benefits. |
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| Subject: | Molecular biology Inflammation Rose |
| Country: | Portugal |
| Document type: | journal article |
| Access type: | Restricted |
| Associated institution: | Angiologia e Cirurgia Vascular |
| Language: | English |
| Origin: | Angiologia e Cirurgia Vascular |
| Summary: | Aims Inflammation is common in clinical practice and often results in significant complications. The study was performed in search of a novel anti-inflammatory agent for inflammation modulation which would be useful for cardiovascular disorders and various clinical scenarios. Materials and methods A crushed red rose extract was prepared from the petals, and it was processed for analysis. The extract was tested on HUVEC cells at various concentrations. By microscopic analysis of cells, a safe concentration was identified, and the levels below the safe limit were tested at 72 hours and seven days for selected cytokines secretion. Results Majority of the tested Inflammatory cytokine secretion was reduced by the treatment of red rose extract on the cells. VEGF and angiogenic cytokine levels were reduced, but VEGF-R2 levels were maintained after the cell treatment. Below the safe concentration limit (0.5%) there were only minimal changes in the cytokines levels tested at various dilutions. Conclusion There is potential for a red rose extract treatment in the regulation of inflammatory cytokines secretion. Further studies need to be performed to identify the benefits. |
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