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Chemistry and biological activities of the marine sponges of the genera mycale (Arenochalina), Biemna and Clathria
| Resumo: | Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today. These marine organisms potentially represent the richest pipeline for novel drug leads. Mycale (Arenochalina) and Clathria are recognized marine sponge genera belonging to the order Poecilosclerida, whereas Biemna was more recently reclassified, based on molecular genetics, as a new order Biemnida. Together, these sponge genera contribute to the production of physiologically active molecular entities with diverse structural features and a wide range of medicinal and therapeutic potentialities. In this review, we provide a comprehensive insight and up-to-date literature survey over the period of 1976–2018, focusing on the chemistry of the isolated compounds from members of these three genera, as well as their biological and pharmacological activities, whenever available. © 2018 by the authors. |
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| Assunto: | guanidine derivative animal antibacterial activity alkaloid Animals drug isolation drug structure neolabuaninen A Mycale chemical analysis drug cytotoxicity mycalazol derivative crambescidin derivative batzelladine derivative metabolism nuclear magnetic resonance spectroscopy drug research antiviral activity mass spectrometry pteridine derivative Aquatic Organisms physical chemistry mycalazal derivative sponge (Porifera) antineoplastic activity clathrynamide A biemnadin clathrynamide B clathrynamide C mass fragmentography cyclopeptide Clathria biological product nonhuman human biological activity Biemna araiosamine A ecionine A Biological Products mirabilin F Molecular Structure natural product mirabilin D mirabilin E 8,9 dihydro 11 hydroxyascididemin mirabilin B mirabilin C mirabilin A chemistry unclassified drug drug classification netamine M n hydroxymethylisocystodamine Porifera araiosamine D isolation and purification araiosamine C araiosamine B Review chemical structure antifungal activity ptilocaulin derivative aquatic species unindexed drug |
| País: | Portugal |
| Tipo de documento: | journal article |
| Tipo de acesso: | Aberto |
| Instituição associada: | Repositório Aberto da Universidade do Porto |
| Idioma: | inglês |
| Origem: | Repositório Aberto da Universidade do Porto |
| _version_ | 1850560635896594432 |
|---|---|
| conditionsOfAccess_str | open access |
| country_str | PT |
| description | Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today. These marine organisms potentially represent the richest pipeline for novel drug leads. Mycale (Arenochalina) and Clathria are recognized marine sponge genera belonging to the order Poecilosclerida, whereas Biemna was more recently reclassified, based on molecular genetics, as a new order Biemnida. Together, these sponge genera contribute to the production of physiologically active molecular entities with diverse structural features and a wide range of medicinal and therapeutic potentialities. In this review, we provide a comprehensive insight and up-to-date literature survey over the period of 1976–2018, focusing on the chemistry of the isolated compounds from members of these three genera, as well as their biological and pharmacological activities, whenever available. © 2018 by the authors. |
| documentTypeURL_str | http://purl.org/coar/resource_type/c_6501 |
| documentType_str | journal article |
| id | af2853f5-e0a0-49f3-aaf3-fb59de9ad285 |
| identifierHandle_str | https://hdl.handle.net/10216/120419 |
| language | eng |
| relatedInstitutions_str_mv | Repositório Aberto da Universidade do Porto |
| resourceName_str | Repositório Aberto da Universidade do Porto |
| spellingShingle | Chemistry and biological activities of the marine sponges of the genera mycale (Arenochalina), Biemna and Clathria guanidine derivative animal antibacterial activity alkaloid Animals drug isolation drug structure neolabuaninen A Mycale chemical analysis drug cytotoxicity mycalazol derivative crambescidin derivative batzelladine derivative metabolism nuclear magnetic resonance spectroscopy drug research antiviral activity mass spectrometry pteridine derivative Aquatic Organisms physical chemistry mycalazal derivative sponge (Porifera) antineoplastic activity clathrynamide A biemnadin clathrynamide B clathrynamide C mass fragmentography cyclopeptide Clathria biological product nonhuman human biological activity Biemna araiosamine A ecionine A Biological Products mirabilin F Molecular Structure natural product mirabilin D mirabilin E 8,9 dihydro 11 hydroxyascididemin mirabilin B mirabilin C mirabilin A chemistry unclassified drug drug classification netamine M n hydroxymethylisocystodamine Porifera araiosamine D isolation and purification araiosamine C araiosamine B Review chemical structure antifungal activity ptilocaulin derivative aquatic species unindexed drug |
| title | Chemistry and biological activities of the marine sponges of the genera mycale (Arenochalina), Biemna and Clathria |
| topic | guanidine derivative animal antibacterial activity alkaloid Animals drug isolation drug structure neolabuaninen A Mycale chemical analysis drug cytotoxicity mycalazol derivative crambescidin derivative batzelladine derivative metabolism nuclear magnetic resonance spectroscopy drug research antiviral activity mass spectrometry pteridine derivative Aquatic Organisms physical chemistry mycalazal derivative sponge (Porifera) antineoplastic activity clathrynamide A biemnadin clathrynamide B clathrynamide C mass fragmentography cyclopeptide Clathria biological product nonhuman human biological activity Biemna araiosamine A ecionine A Biological Products mirabilin F Molecular Structure natural product mirabilin D mirabilin E 8,9 dihydro 11 hydroxyascididemin mirabilin B mirabilin C mirabilin A chemistry unclassified drug drug classification netamine M n hydroxymethylisocystodamine Porifera araiosamine D isolation and purification araiosamine C araiosamine B Review chemical structure antifungal activity ptilocaulin derivative aquatic species unindexed drug |