Publication

Effects of environmental pollutants on MCF-7 Cells: A metabolic approach

Bibliographic Details
Summary:Several environmental pollutants (EPs) have been associated with biological and molecular processes leading to adverse human health effects, including different types of cancer. Nevertheless, the effects exerted on tumor glucose metabolism are unclear. To evaluate the effects on cellular and molecular mechanisms, namely glucose metabolism, MCF-7 cells were exposed to EPs during short- and long-term exposures. The effect of both, organochlorine pesticides and plasticizing agents, on glucose uptake by MCF-7 cells was not dose-dependent and was affected by time of exposure. The HCH and BPA increased glucose uptake after 20min. Long-term exposure to 250nM of organochlorine pesticides (p,p'-DDE and HCH) and BPA increased cell proliferation. However, only the organochlorine pesticides were able to increase lactate production, without a concomitant higher glucose uptake or glycolytic enzymes transcription. Given their distinct persistent profiles, the biological significance of their exposure should be considered accordingly
Subject:Ciências da Saúde, Ciências médicas e da saúde Health sciences, Medical and Health sciences
Country:Portugal
Document type:journal article
Access type:Restricted
Associated institution:Repositório Aberto da Universidade do Porto
Language:English
Origin:Repositório Aberto da Universidade do Porto

Similar Items

Similar Items