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COLITE ISQUÉMICA COMO MARCADOR PRECOCE DE ISQUEMIA MESENTÉRICA AGUDA

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Summary:	Introduction: Acute mesenteric ischemia (AMI) and colonic ischemia (CI) may be quite intricate and appear in the same patient simultaneously or in different time frames. However, in the majority of patients with CI a specific occlusive vascular lesion cannot be identified, as opposed to AMI. According to the American College of Gastroenterology (ACG), CT angiography should be performed in all patients with severe CI in order to exclude AMI. The main purposes of this study were to stratify CI severity to determine if there was an association with the presence of AMI, and to identify determinants of AMI in severe CI. Methods: The clinical data of all patients admitted with the diagnosis of CI from 2010 to 2014 were retrospectively reviewed. Results: A total of 241 patients were included, 213 with isolated CI and 28 with CI+AMI. CI was stratified according to ACG severity classification. No cases of concomitant AMI were found in mild CI, 1.5% of patients with moderate CI and 56.8% of patients with severe CI had simultaneously AMI. The severe isolated CI was compared with the severe CI+AMI group. Hematochezia was found more frequently in isolated CI (p<0.001) whereas constipation and isolated right CI were more common in the CI+AMI group (p=0,021). At admission haemoglobin level was significantly higher in the CI+AMI (13.8±1.9 Vs 11.4±2.2; p<0.001) as was lactate level (7.6±4.6 Vs 2.4±1.3; p=0.001). Atrial fibrillation, coronary disease and isolated right colon ischemia were more common in the CI+AMI group (p<0.05). Other clinical findings were evaluated with no significant difference between groups. Conclusions: The knowledge of an association between CI and AMI prompts to look for underlying occlusive disease in patients with severe CI. Our results based on the analysis of 241 patients with CI support the ACG recommendation for CT angiography in all patients with severe CI. Elevated lactate level, right isolated CI, atrial fibrillation and coronary disease are predictors of AMI in patients with severe CI in this study.
Subject:	Acute mesenteric ischemia Diagnóstico precoce Early diagnosis Colite isquémica Colon ischemia Isquemia mesentérica aguda
Country:	Portugal
Document type:	journal article
Access type:	Restricted
Associated institution:	Angiologia e Cirurgia Vascular
Language:	Portuguese
Origin:	Angiologia e Cirurgia Vascular