Publicação

Salt intake and risk of gastric intestinal metaplasia: systematic review and meta-analysis

Detalhes bibliográficos
Resumo:	The understanding of the association between salt intake and precancerous lesions may contribute to clarify the causal relation with gastric cancer. We systematically reviewed 17 articles addressing the association between dietary salt exposure and gastric intestinal metaplasia and conducted meta-analyses for quantitative synthesis (random effects model). Salt exposure was estimated assessing salted/salty food consumption, preference for salted/salty foods, use of table salt, or sodium urinary excretion. Heterogeneity was also large regarding food items evaluated, consumption categories, and data analysis. The combined odds ratio (OR) was 1.68 (95% confidence interval (CI) = 0.98–2.90; I2 = 55.4%) for the association between salted/salty meat and intestinal metaplasia (4 studies) and the OR was 1.53 (95% CI = 0.72–3.24; I2 = 76.8%) for salt preference. There was a positive, nonstatistically significant association between intestinal metaplasia and urinary sodium excretion. The heterogeneity of methodological options and results preclude quantitative synthesis or its proper interpretation, even if the available evidence may suggest a positive association between salt and intestinal metaplasia.
País:	Portugal
Tipo de documento:	journal article
Tipo de acesso:	Restrito
Instituição associada:	Repositório Aberto da Universidade do Porto
Idioma:	inglês
Origem:	Repositório Aberto da Universidade do Porto

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conditionsOfAccess_str	restricted access
country_str	PT
description	The understanding of the association between salt intake and precancerous lesions may contribute to clarify the causal relation with gastric cancer. We systematically reviewed 17 articles addressing the association between dietary salt exposure and gastric intestinal metaplasia and conducted meta-analyses for quantitative synthesis (random effects model). Salt exposure was estimated assessing salted/salty food consumption, preference for salted/salty foods, use of table salt, or sodium urinary excretion. Heterogeneity was also large regarding food items evaluated, consumption categories, and data analysis. The combined odds ratio (OR) was 1.68 (95% confidence interval (CI) = 0.98–2.90; I2 = 55.4%) for the association between salted/salty meat and intestinal metaplasia (4 studies) and the OR was 1.53 (95% CI = 0.72–3.24; I2 = 76.8%) for salt preference. There was a positive, nonstatistically significant association between intestinal metaplasia and urinary sodium excretion. The heterogeneity of methodological options and results preclude quantitative synthesis or its proper interpretation, even if the available evidence may suggest a positive association between salt and intestinal metaplasia.
documentTypeURL_str	http://purl.org/coar/resource_type/c_6501
documentType_str	journal article
id	09f33768-7ad8-4706-b930-5a51ba013e4b
identifierHandle_str	https://hdl.handle.net/10216/160715
language	eng
relatedInstitutions_str_mv	Repositório Aberto da Universidade do Porto
resourceName_str	Repositório Aberto da Universidade do Porto
spellingShingle	Salt intake and risk of gastric intestinal metaplasia: systematic review and meta-analysis
title	Salt intake and risk of gastric intestinal metaplasia: systematic review and meta-analysis